Peer-Reviewed Publications 

2024

• Subramanian, D., Eisenberg, C., Huang, A., Baek, J., Naveed, H., Komatireddy, S., Shiflett, M.W., Tran, T.S., Santhakumar, V. (2024) Dysregulation of neuropilin-2 expression in inhibitory neurons impairs hippocampal circuit development and enhances risk for autism-related behaviors and seizures Molecular Psychiatry. doi: 10.1038/s41380-024-02839-4. PMID: 38370800

2023

• Shao, M., Yu, H., Santhakumar, V., Yu, J. (2023) Antiepileptogenic and neuroprotective effect of mefloquine after experimental status epilepticus Epilepsy Research. doi:10.1016/j.eplepsyres.2023.107257.
• Proddutur, A., Nguyen, S., Yeh, C.W., Gupta, A., Santhakumar, V. (2023) Reclusive chandeliers: Functional isolation of dentate axo-axonic cells after experimental status epilepticus  Progress in Neurobiology. doi:10.1016/j.pneurobio.2023.102542. PMID: 37898313
• Yeh, C.W., Huang, A. (2023) Deathtouch: The Long and Selective Reach of Proneurotrophin Shapes Neurodegeneration after Concussive Brain Injury eNeuro. doi:10.1523/ENEURO.0340-23.2023. PMID: 37884345
• Corrubia, L., Huang, A., Nguyen, S., Shiflett, M.W., Jones, M.V., Ewell, L.A., Santhakumar, V. (2023) Early Deficits in Dentate Circuit and Behavioral Pattern Separation after Concussive Brain Injury Experimental Neurology. doi:10.1016/j.expneurol.2023.114578. PMID: 37745454

2022

• Dovek L. Remind Me, My Memory Is All Shook Up. eNeuro. doi:10.1523/ENEURO.0379-22.2022. PMID: 36257693
• Gupta, A., Dovek, L., Proddutur, A., Elgammal, F. S., & Santhakumar, V. (2022). Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells Frontiers in Neuroscience. doi:10.3389/fnins.2022.800733. PMID: 35360164.
• Afrasiabi M, Gupta A, Xu H, Swietek B, Santhakumar V. (2022) Differential Activity-Dependent Increase in Synaptic Inhibition and Parvalbumin Interneuron Recruitment in Dentate Granule Cells and Semilunar Granule Cells. J Neuro. doi:10.1523/JNEUROSCI.1360-21.2021. PMID: 34980636.

2021

• Eisenberg C, Subramanian D, Afrasiabi M, Ziobro P, DeLucia J, Hirschberg PR, Shiflett MW, Santhakumar V, Tran TS. (2021) Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2. Translational Psychiatry. doi:10.1038/s41398-021-01655-6. PMID: 34663783.
• Ubina T, Vahedi-Hunter T, Agnew-Svoboda W, Wong W, Gupta A, Santhakumar V, Riccomagno MM. (2021) ExBoX - a simple Boolean exclusion strategy to drive expression in neurons. J Cell Sci. doi:10.1242/jcs.257212. PMID: 34515305.
• Chitturi J, Santhakumar V, Kannurpatti SS. (2021) Traumatic brain injury metabolome and mitochondrial impact after early stage Ru360 treatment. Mitochondrion. doi:10.1016/j.mito.2021.01.003. PMID: 33484870

2020

• Gupta, A., Proddutur, A., Chang, Y.-J., Raturi, V., Guevarra, J., Shah, Y., … Santhakumar, V. (2020). Dendritic morphology and inhibitory regulation distinguish dentate semilunar granule cells from granule cells through distinct stages of postnatal development.  Brain Structure and Function, 225(9), 2841–2855. 
• Nguyen, S., & Santhakumar, V. (2020). From Plugging the Dam to Fueling the Firing: Platelets Breach the Barrier to Seize the Brain. Epilepsy Currents, 20(5), 300–302. (Refereed, Invited) 
• Hamilton, K. A., & Santhakumar, V. (2020). Current ex Vivo and in Vitro Approaches to Uncovering Mechanisms of Neurological Dysfunction after Traumatic Brain Injury. Current Opinion in Biomedical Engineering.Volume 14, 2020,Pages 18-24.
• Korgaonkar, A. A., Nguyen, S., Li, Y., Sekhar, D., Subramanian, D., Guevarra, J.,Pang, K, Santhakumar, V. (2020). Distinct cellular mediators drive the Janus Faces of Toll-like Receptor 4 regulation of network excitability which impacts working memory performance after brain Injury. Brain, Behavior, and Immunity.,S0889-1591(19)31078-5.
• Parent, M., Chitturi, J., Santhakumar, V., Hyder, F., Sanganahalli, B. G., & Kannurpatti, S. S. (2020). Kaempferol Treatment after Traumatic Brain Injury during Early Development Mitigates Brain Parenchymal Microstructure and Neural Functional Connectivity Deterioration at Adolescence. Journal of Neurotrauma, 37(7), 966–974.
• Korgaonkar, A. A., Li, Y., Sekhar, D., Subramanian, D., Guevarra, J., Swietek, B.,  Pallottie A, Singh S, Kella K, Elkabes S, Santhakumar, V. (2020). TLR4 signaling in neurons enhances calcium‐permeable AMPAR currents and drives post‐traumatic epileptogenesis. Annals of Neurology, 87(4):497-515.

2019

• Corrubia, L., & Santhakumar, V. (2019). Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control. Epilepsy Currents, 20(1), 57–60.
• Zanin JP, Verpeut JL, Li Y, Shiflett MW, Wang SS, Santhakumar V, Friedman WJ. (2019) The p75NTR Influences Cerebellar Circuit Development and Adult Behavior via Regulation of Cell Cycle Duration of Granule Cell Progenitors. J Neurosci. 2019 Nov 13;39(46):9119-9129. doi: 10.1523/JNEUROSCI.0990-19.2019. Epub 2019 Oct 
• Subramanian D, Santhakumar V (2019), Goldilocks Zone of Ictal Onset: Partially Recovered Synapses Provide the Kindling to Fuel Ictal ActivityEpilepsy Curr. 2019 Sep-Oct; 19(5): 330–332. doi: 10.117707/15357597198696
• Chitturi J, Li Y, Santhakumar V, Kannurpatti SS (2019) Consolidated Biochemical Profile of Subacute Stage Traumatic Brain Injury in Early Development Front Neurosci 13,431, DOI : 10.3389/fnins.2019.00431.
• Chitturi J, Santhakumar V, Kannurpatti SS. (2019) Beneficial Effects of Kaempferol after Developmental Traumatic Brain Injury Is through Protection of Mitochondrial Function, Oxidative Metabolism, and Neural Viability.  J Neurotrauma. 2019 Jan 8. doi: 10.1089/neu.2018.6100. 

2018

• Chitturi J, Li Y, Santhakumar V, Kannurpatti SS.(2018)  Early behavioral and metabolomic change after mild to moderate traumatic brain injury in the developing brain.  Neurochem Int. 2018 Nov;120:75-86. doi: 10.1016/j.neuint.2018.08.003.
• Parent M, Li Y, Santhakumar V, Hyder F, Sanganahalli BG, Kannurpatti SS. (2018) Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development. J Neurotrauma. 2018 Aug 13. doi: 10.1089/neu.2018.5741.
• Gupta A, Santhakumar V (2018) Reefer to the Rescue: The Dope on Cannabidiol as a Multi-Symptom Panacea for Dravet Syndrome. Epilepsy Curr. 2018 Mar-Apr;18(2):118-120. doi: 10.5698/1535-7597.18.2.118.

2017

• Neuberger EJ, Gupta A, Subramanian  D,  Korgaonkar AA,  Santhakumar, V (2017) Converging early responses to brain injury pave the road to epileptogenesis. J.Neurosci.Res, doi: 10.1002/jnr.24202.
• Neuberger EJ, Swietek B, Corrubia L, Prasanna A, Santhakumar, V.(2017) Enhanced Dentate Neurogensis after Brain Injury Undermines Long -Term Neurogenic Potential and Promotes Seizure Susceptibility. Stem Cell Reports 2017 Sep 12;9(3):972-984. doi: 10.1016/j.stemcr.2017.07.015.
• Subramanian, D, Santhakumar, V (2017). Lighting the Fuse: Deconstucting Complex Network Interactions Using On-Demand Seizures. Epilepsy Currents Invited Commentary, May-Jun;17(3):174-176.

2016

• Swietek, B., Gupta, A., Proddutur, A., Santhakumar, V.(2016) Immunostaining of Biocytin-filled and Processed Sections for Neurochemical Markers. J. Vis. Exp. (118), e54880, doi:10.3791/54880.
• Abdul-Muneer PM, Long M, Conte AA, Santhakumar V, Pfister BJ, (2016). High Ca2+ influx during traumatic brain injury leads to Caspase-1-Dependent neuroinflammation and cell death. Molecular Neurobiology. DOI:10.1007/s12035-016-9949-4.
• Gupta, A, Santhakumar, V (2016). Illuminating the Role for Chloride Dysregulation in Network Activity. Epilepsy Currents, Jul-Aug;16(4):258-260.
• Murugan M, Santhakumar V, Kannurpatti S (2016). Activation-induced spatiotemporal cerebral blood flow changes and behavioral deficit after mTBI in immature rats can be favorably altered by facilitating mitochondrial calcium uptake. Frontiers in Systems Neuroscience. DOI: 10.3389/fnsys.2016.00019.
• Yu J, Swietek B, Proddutur A, Santhakumar V (2016). Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiology of Disease. Jan, 21; 89:23-35. DOI:10.2016/j.nbd.2016.01.013.
• Proddutur A, Santhakumar V (2016). Fingerprints of interictal spikes: Can imprints deliver a verdict on their role in epilepsy? Epilepsy Currents. Jan-Feb;16(1):41-2. DOI: 10.5698/1535-7597-16.1.41.

2015

• Yu J, Proddutur A, Swietek B, Elgammal F, Santhakumar V (2015). Functional reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms. Cerebral Cortex. DOI: 10.1093/cercor/bhv199.
• Proddutur A, Santhakumar V (2015). Marching towards a Seizure: Spatio-temporal Evolution of Preictal activity., Epilepsy Currents.Sep-Oct; 15(5): 267–268.
• Wahab RA, Neuberger EJ, Lyeth BG, Santhakumar V, Pfister BJ (2015)., Percussion Injury Device for the Precise Control of Injury Parameters.Journal of Neuroscience Methods. Jun 15;248:16-26. DOI: 10.1016/j.jneumeth.2015.03.010.
• Yu J, Swietek B, Proddutur A, Santhakumar V, (2015)., Dentate total molecular layer interneurons mediate cannabinoid-sensitive inhibition. Hippocampus. Aug;25(8):884-9. DOI: 10.1002/hipo.22419.
• Li Y*, Korgaonkar A*, Swietek B , Wang J, Elgammal FS, Elkabes, S,Santhakumar V (2015). Toll-like receptor 4 augments mossy cell AMPA currents and contributes to NMDA receptor-independent increase in dentate excitability after brain injury. Neurobiology of Disease. DOI: 10.1016/j.nbd.2014.11.021* Equal Contribution.

2014

• Pang KCH, Sinha S, Avcu P, Roland JJ, Nadpara N, Pfister BJ, Long M,   Santhakumar V, Servatius RJ. (2014)., Long-lasting suppression of acoustic startle response following mild traumatic brain injury. Journal of Neurotrauma. DOI:10.1089/neu.2014.3451.
• Ordek G, Proddutur A, Santhakumar V, Pfister BJ, Sahin M (2014)., Electrophysiological Monitoring of Injury Progression in the Rat Cerebellar Cortex. Frontiers in Systems Neuroscience Oct 9;8:197. DOI: 10.3389/fnsys.2014.00197. eCollection 2014.
• Neuberger EJ*, Abdul Wahab R, Jaykumar A, Pfister BJ, Santhakumar V (2014)., Distinct effect on impact rise times on immediate and early neuropathology after brain injury in juvenile rats. Journal of Neuroscience Research. 05 May 2014.

2013

• Proddutur A, Yu J, Elgammal FS, Santhakumar V (2013)., Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations. Chaos. 20 November. 23, 046109.
• Santhakumar V, Pratap M, Karakossian MH, Otis TS (2013)., A reinforcing circuit action of extrasynaptic GABA(A) receptor modulators on cerebellar granule cell inhibition. PLOS ONE 2013 Aug 19;8(8):e72976.
• Yu J, Proddutur A, Elgammal FS, Ito T,   Santhakumar V (2013)., Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells. The Journal of Neurophysiology 109: 1746-1763. Also featured in Global Medical Discovery.

2012

• Gupta A, Elgammal FS, Proddutur A, Shah S,   Santhakumar V (2012)., Decrease in Tonic Inhibition Contributes to Increase in Dentate Semilunar Granule Cell Excitability after Brain Injury. The Journal of Neuroscience 32(7): 2523-2537.Also featured in Psychology Progress

2010 and earlier 

• Santhakumar V, Jones RT., Mody I (2010)., Developmental Regulation and Neuroprotective Effects of Striatal Tonic GABAa Currents. Neuroscience 167(3):644-55.
• Santhakumar V, Wallner M, Otis TS, (2007)., Ethanol acts Directly on Extrasynaptic Subtypes of GABAa Receptors to Increase Tonic Inhibition. Alcohol 41(3):211-221.
• Dyhrfjeld-Johnsen J*, Santhakumar V*, Morgan R, Huerta R, Tsimring L, Soltesz I (2007).,  Topological Determinants of Epileptogenesis in Large-Scale Structural and Functional Models of the Dentate Gyrus Derived from Experimental Data. Journal of Neurophysiology 97(2):1566-1587.
• Santhakumar V, Hanchar HJ, Wallner M, Olsen RW & Otis TS (2006)., Contributions of the GABAA Receptor Subunit a6 to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the a6 Gene. Journal of Neuroscience 26(12):3357 –3364.
• Santhakumar V, Aradi I, Soltesz I (2005)., Role of Mossy Fiber Sprouting and Mossy Cell Loss in Hyperexcitability: A Network Model of the Dentate Gyrus Incorporating Cell Types and Axonal Topography. Journal of Neurophysiology 93(1):437-53.
• Santhakumar V and Soltesz I (2004) Heterogeneity on the Move: Plasticity of Interneuronal Species Diversity and Parameter Variance in Neurological Diseases. Trends in Neuroscience 27(8):504-10.
• Aradi I*, Santhakumar V*, Soltesz I (2004)., Simple Rules Govern the Impact of Heterogeneous Perisomatic IPSC Populations on Pyramidal Cell Firing Rates. Journal of Neurophysiology 91: 2849–2858.
• Ratzliff AH, Howard A, Santhakumar V, Osapay I, Soltesz I (2004)., Rapid Deletion of Mossy Cells Does Not Result in a Hyperexcitable Dentate Gyrus: Implications for Epileptogenesis. Journal of Neuroscience 24(9):2259 –2269.
• Santhakumar V, Voipio J, Kaila K, Soltesz I (2003).,  Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassium. Journal of Neuroscience 23(13):5865-76.
• Aradi I, Santhakumar V, Chen K, Soltesz I (2002)., Postsynaptic effects of GABAergic synaptic diversity: regulation of neuronal excitability by changes in IPSC variance. Neuropharmacology 43: 511-522.
• Chen K, Aradi I, Santhakumar V, Soltesz I (2002) H-channels in epilepsy: new targets for seizure control? Trends in Pharmacological Sciences 23: 552-557.
• Ratzliff AH, Santhakumar V, Howard A, Soltesz I (2002) Mossy cells in epilepsy: rigor mortis or vigor mortis? Trends in Neuroscience 25: 140-144.
• Santhakumar V, Ratzliff AD, Jeng J, Toth K, Soltesz I (2001).,   Long-term hyperexcitability in the hippocampus after experimental head trauma. Annals of Neurology 50: 708-717.
• Santhakumar V, Bender R, Frotscher M, Ross ST, Hollrigel GS, Toth Z, Soltesz I (2000)., Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis. Journal of Physiology (London) 524 Pt 1: 117-134.

Book Chapters

• Veerasammy S, Kumari E, Goodus MT,  Neuberger EJ, , Santhakumar V  and Levison SW  (2017) . Consequences of Inflammation Within Neural Stem Cell Niches On Development And Regeneration In The Immature Brain. 2nd edition  of the Frontiers in Stem Cell and Regenerative Medicine research e-Book, edited by Drs. Atta-Ur-Rahman and Anjum. Vol.7, 43-91.
• Santhakumar V (2008), Modeling mossy cell loss and mossy fiber sprouting in epilepsy In: Computational Neuroscience in Epilepsy edited by Soltesz I and Staley K.J. Academic Press. 89-111.
• Morgan R, Santhakumar V, Soltesz I (2007), Modeling the Dentate Gyrus In: The Dentate Gyrus edited by Scharfman H. Elsevier press. Progress in Brain Research 163C:639-658.